In Silico Medicine: Leveraging Biosimulation and Mathematical Modeling to Predict Drug Efficacy, Optimize Clinical Trial Design, and Accelerate the Development Timeline for New and Safer Pharmaceuticals
Biosimulation is the use of computational models and mathematical equations to represent and predict the dynamic behavior of biological systems, from individual cells and organs to the entire human body. Often referred to as "in silico" biology, this technology is revolutionizing pharmaceutical research and development by providing a powerful, cost-effective alternative to purely in vivo (animal/human) and in vitro (lab-dish) experiments. Physiologically Based Pharmacokinetic (PBPK) models, a key application, accurately simulate how a drug is absorbed, distributed, metabolized, and excreted (ADME) in diverse patient populations—such as pediatric, elderly, or organ-impaired patients—who are often excluded from traditional clinical trials.